Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Substance use disorder is characterized by repeated use of a substance, leading to
clinically significant distress, making it a serious public health concern. The …

Recent studies have shown that the endocannabinoid system is involved in the common
neurobiological mechanism underlying drug addiction. This system participates in the …

Cannabinoid drugs such as Δ 9-THC are euphoric and rewarding, and also stimulate food
intake in humans and animals. Little is known about how naturally occurring endogenous …

BACKGROUND: Although heavy smoking has been associated with impulsivity in humans, it
is not clear whether poor impulse control represents a risk factor in the etiology of nicotine …

With no further intervention, relapse rates in detoxified alcoholics are high and usually
exceed 80% of all detoxified patients. It has been suggested that stress and exposure to …

Addiction can be viewed as a form of drug-induced neural plasticity. One of the best
established molecular mechanisms of addiction is the upregulation of the cAMP second …