The murine developmental mutation T identifies an essential gene in mesoderm formation.
Embryos lacking normal gene activity fail to form the notochord, the entire posterior region …

▪ Abstract The most studied example of transmission ratio distortion (TRD) in mice is that of
the t-complex. This is a variant region of Chromosome 17 which exists as a polymorphism in …

Spinal muscular atrophy (SMA) is a common fatal autosomal recessive disorder
characterized by degeneration of lower motor neurons, leading to progressive paralysis with …

Tuberous sclerosis (TSC) is an autosomal dominant multisystem disorder with loci assigned
to chromosomes 9 and 16. Using pulsed-field gel electrophoresis (PFGE), we identified five …

Summary Charcot-Marie-Tooth disease type 1 A (CMTi A) was localized by genetic mapping
to a 3 CM interval on human chromosome 17~. DNA markers within this interval revealed a …

T-ASSOCIATED maternal effect (Tme) is the only known maternal-effect mutation in the
mouse1, 2. The defect is nuclear-encoded3 and embryos that inherit a deletion of the Tme …

In the central nervous system (CNS), the principal mediators of fast synaptic excitatory
neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate …

CYTOGENETIC analysis has identified chromosome Ilpl3 as the smallest overlap region for
deletions found in individuals with WAGR syndrome, which includes Wilms tumour (a …

Major genes which cause tuberous sclerosis (TSC) and autosomal dominant polycystic
kidney disease (ADPKD), known as TSC2 and PKD1 respectively, lie immediately adjacent …

The mouse insulin-like growth factor type 2 receptor (Igf2r) is imprinted and expressed
exclusively from the maternally inherited chromosome. To investigate whether methylation …