The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

The expression of matrix metalloproteinase-2 (MMP-2) has been linked with tumor invasion,
angiogenesis, and metastasis. However, the molecular basis for MMP-2 overexpression in …

Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …

The Y‐box‐binding protein (YB‐1) represents the most evolutionary conserved nucleic‐acid‐
binding protein currently known. YB‐1 is a member of the cold‐shock domain (CSD) protein …

Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

Abstract E2F transcription factor 1 (E2F1) is a member of the E2F family of transcription
factors. E2F1 binds to DNA with dimerization partner (DP) proteins through an E2 …

Progressive renal interstitial fibrosis and tubular atrophy represent the final injury pathway
for all commonly encountered forms of renal disease that lead to end-stage renal failure. It …

Matrix metalloproteinases (MMPs) are a family of zinc‐dependent proteolytic enzymes that
function mainly in the extracellular matrix, where they contribute to the development …

Discoidin domain receptor 2 (DDR2) is a tyrosine kinase receptor expressed in
mesenchymal tissues, the ligand of which is fibrillar collagen. We have compared DDR2 …