Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Improvements in medical interventions for people with Down's syndrome have led to a
substantial increase in their longevity. Diagnosis and treatment of neurological …

In this article, we first present a summary of the general assumptions about Down syndrome
(DS) still to be found in the literature. We go on to show how new research has modified …

Scope Trisomy for human chromosome 21 results in D own syndrome (DS), which is among
the most complex genetic perturbations leading to intellectual disability. Accumulating data …

Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …

Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …

Down syndrome (DS) is the most frequent genetic disorder leading to intellectual disabilities
and is caused by three copies of human chromosome 21. Mouse models are widely used to …

Deviation from a balanced genome by either gain or loss of entire chromosomes is generally
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …

Down syndrome (DS) is one of the most frequent genetic abnormalities characterized by
multiple pathological phenotypes. Indeed, currently life expectancy and quality of life for DS …

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …