Objective To conduct a systematic review and meta-analysis of cohort studies of body mass
index (BMI) and the risk of all cause mortality, and to clarify the shape and the nadir of the …

By the year 2050, individuals over the age of 65 years will comprise 20% of the US
population. Loss of muscle mass and strength is common in this age group and it is …

In 2008, we published an article arguing that the age-related loss of muscle strength is only
partially explained by the reduction in muscle mass and that other physiologic factors …

Cachexia is a serious, however underestimated and underrecognised medical
consequence of malignant cancer, chronic heart failure (CHF), chronic kidney disease …

It is estimated that half of all patients with cancer eventually develop a syndrome of
cachexia, with anorexia and a progressive loss of adipose tissue and skeletal muscle mass …

Disease-related malnutrition is highly prevalent among cancer patients, with 40–80%
suffering from it during the course of their disease. Malnutrition is associated with numerous …

Background Cachexia, also known as muscle wasting, is a complex metabolic condition
characterized by loss of skeletal muscle and a decline in physical function. Muscle wasting …

Adult skeletal tissue is composed of heterogeneous population of cells that constantly self-
renew by means of a controlled process of activation and proliferation of tissue-resident …

Background Cachexia, or weight loss despite adequate nutrition, significantly impairs quality
of life and response to therapy in cancer patients. In cancer patients, skeletal muscle …

The gut microbiota has recently been proposed as a novel component in the regulation of
host homeostasis and immunity. We have assessed for the first time the role of the gut …