Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Peripheral neuropathy is a common and debilitating complication of diabetes and
prediabetes. Recent clinical studies have identified an association between the …

Obesity is a global epidemic that is caused by excessive energy intake or inefficient energy
expenditure. Brown or beige fat dissipates energy as heat through non-shivering …

The caseinolytic peptidase P (CLPP) is conserved from bacteria to humans. In the
mitochondrial matrix, it multimerizes and forms a macromolecular proteasome-like cylinder …

Ferroptosis is a major cause of cardiotoxicity induced by doxorubicin (DOX). Previous
studies have shown that hydrogen sulfide (H 2 S) inhibits ferroptosis in cardiomyocytes and …

Background: Increasing childhood obesity is a global issue requiring potentially local
solutions to ensure it does not continue into adulthood. We systematically identified …

An increase in energy intake and/or a decrease in energy expenditure lead to fat storage,
causing overweight and obesity phenotypes. The objective of this review was to analyse, for …

A growing number of inborn errors of metabolism (IEM) associated with compromised
mitochondrial energy metabolism manifest an unusual phenotypic feature: 3 …

ABSTRACT Optic atrophy 3 (OPA3) is an integral protein of the mitochondrial outer
membrane. The current study explored the expression of OPA3 in hepatocellular carcinoma …

Inherited neurodegeneration of the optic nerve is a paradigm in neurology, as many forms of
isolated or syndromic optic atrophy are encountered in clinical practice. The retinal ganglion …