The pentose phosphate pathway (PPP), which branches from glycolysis at the first
committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is …

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …

Energy metabolism is significantly reprogrammed in many human cancers, and these
alterations confer many advantages to cancer cells, including the promotion of biosynthesis …

Recent studies have established that tumors can reprogram the pathways involved in
nutrient uptake and metabolism to withstand the altered biosynthetic, bioenergetics and …

The pentose phosphate pathway, one of the main antioxidant cellular defense systems, has
been related for a long time almost exclusively to its role as a provider of reducing power …

In the past decade, there has been a resurgence of interest in elucidating how metabolism is
altered in cancer cells and how such dependencies can be targeted for therapeutic gain. At …

Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are
characterized by a high metabolic plasticity resulting from mutations and the selection of …

Re-programming of metabolic pathways is a hallmark of physiological changes in cancer
cells. The expression of certain genes that directly control the rate of key metabolic pathways …

The von Hippel–Lindau (VHL) tumor suppressor gene is mutated as an early event in almost
all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer …

Cancer is a genetic disease that is caused by mutations in oncogenes, tumor suppressor
genes and stability genes. The fact that the metabolism of tumor cells is altered has been …