Targeting the translation machinery in cancer
Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …
tumour suppressors affect the translation machinery, making aberrant translation a …
[HTML][HTML] mRNA cap regulation in mammalian cell function and fate
A Galloway, VH Cowling - Biochimica et Biophysica Acta (BBA)-Gene …, 2019 - Elsevier
In this review we explore the regulation of mRNA cap formation and its impact on
mammalian cells. The mRNA cap is a highly methylated modification of the 5′ end of RNA …
mammalian cells. The mRNA cap is a highly methylated modification of the 5′ end of RNA …
Eukaryotic translation initiation factors as promising targets in cancer therapy
P Hao, J Yu, R Ward, Y Liu, Q Hao, S An… - Cell Communication and …, 2020 - Springer
The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for
gene expression, and occurs principally at the initiation phase which is mainly regulated by …
gene expression, and occurs principally at the initiation phase which is mainly regulated by …
Signalling to eIF4E in cancer
N Siddiqui, N Sonenberg - Biochemical Society Transactions, 2015 - portlandpress.com
Translational control plays a critical role in the regulation of gene expression in eukaryotes
and affects many essential cellular processes, including proliferation, apoptosis and …
and affects many essential cellular processes, including proliferation, apoptosis and …
Translation initiation by cap‐dependent ribosome recruitment: Recent insights and open questions
NE Shirokikh, T Preiss - Wiley Interdisciplinary Reviews: RNA, 2018 - Wiley Online Library
Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …
decode the messenger RNA template by cycling through translation initiation, elongation …
eIF4F: a retrospective
WC Merrick - Journal of Biological Chemistry, 2015 - ASBMB
The original purification of the heterotrimeric eIF4F was published over 30 years ago (Grifo,
JA, Tahara, SM, Morgan, MA, Shatkin, AJ, and Merrick, WC (1983) J. Biol. Chem. 258, 5804 …
JA, Tahara, SM, Morgan, MA, Shatkin, AJ, and Merrick, WC (1983) J. Biol. Chem. 258, 5804 …
Molecular architecture of 4E-BP translational inhibitors bound to eIF4E
D Peter, C Igreja, R Weber, L Wohlbold, C Weiler… - Molecular cell, 2015 - cell.com
The eIF4E-binding proteins (4E-BPs) represent a diverse class of translation inhibitors that
are often deregulated in cancer cells. 4E-BPs inhibit translation by competing with eIF4G for …
are often deregulated in cancer cells. 4E-BPs inhibit translation by competing with eIF4G for …
Control of the eIF4E activity: structural insights and pharmacological implications
The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …
translation has been clearly assessed in the last decades. eIF4E function is essential for …
A quick guide to small-molecule inhibitors of eukaryotic protein synthesis
SE Dmitriev, DO Vladimirov, KA Lashkevich - Biochemistry (Moscow), 2020 - Springer
Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …
Emerging roles of allosteric modulators in the regulation of protein‐protein interactions (PPIs): A new paradigm for PPI drug discovery
Protein‐protein interactions (PPIs) are closely implicated in various types of cellular activities
and are thus pivotal to health and disease states. Given their fundamental roles in a wide …
and are thus pivotal to health and disease states. Given their fundamental roles in a wide …