piRNA-guided CRISPR-like immunity in eukaryotes

Y Ophinni, U Palatini, Y Hayashi, NF Parrish - Trends in Immunology, 2019 - cell.com
Eukaryotic genomes contain virus-derived sequences called endogenous virus elements
(EVEs). The majority of EVEs are related to retroviruses, which integrate into the host …

What are the functional roles of Piwi proteins and piRNAs in insects?

D Santos, M Feng, A Kolliopoulou, CNT Taning, J Sun… - Insects, 2023 - mdpi.com
Simple Summary Three small RNA pathways, representing miRNAs, siRNAs and piRNAs,
exist in insects. Of the three pathways, piRNAs and Piwi proteins appear to have the most …

Improved reference genome of the arboviral vector Aedes albopictus

U Palatini, RA Masri, LV Cosme, S Koren… - Genome biology, 2020 - Springer
Abstract Background The Asian tiger mosquito Aedes albopictus is globally expanding and
has become the main vector for human arboviruses in Europe. With limited antiviral drugs …

Population genomics in the arboviral vector Aedes aegypti reveals the genomic architecture and evolution of endogenous viral elements

CM Crava, FS Varghese, E Pischedda… - Molecular …, 2021 - Wiley Online Library
Horizontal gene transfer from viruses to eukaryotic cells is a pervasive phenomenon.
Somatic viral integrations are linked to persistent viral infection whereas integrations into …

In and outs of Chuviridae endogenous viral elements: origin of a potentially new retrovirus and signature of ancient and ongoing arms race in mosquito genomes

FZ Dezordi, CRS Vasconcelos, AM Rezende… - Frontiers in …, 2020 - frontiersin.org
Background Endogenous viral elements (EVEs) are sequences of viral origin integrated into
the host genome. EVEs have been characterized in various insect genomes, including …

An evolutionary perspective on vector-borne diseases

JR Powell - Frontiers in Genetics, 2019 - frontiersin.org
Several aspects of the biology of the three players in a vector-borne disease that affect their
evolutionary interactions are outlined. A model of the origin of a human–human cycle of …

[HTML][HTML] Endogenous viral elements in mosquito genomes: current knowledge and outstanding questions

U Palatini, CA Contreras, L Gasmi… - Current Opinion in Insect …, 2022 - Elsevier
Highlights•Nonretroviral RNA viruses Endogenous Viral Elements (nrEVEs) are ten folds
more abundant in Aedes than all other mosquitoes.•Aedes nrEVEs are enriched in piRNA …

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors: the interaction with the RNAi mechanism

J Liu, L Swevers, A Kolliopoulou… - Frontiers in physiology, 2019 - frontiersin.org
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do
not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled …

Co-option of a non-retroviral endogenous viral element in planthoppers

HJ Huang, YY Li, ZX Ye, LL Li, QL Hu, YJ He… - Nature …, 2023 - nature.com
Non-retroviral endogenous viral elements (nrEVEs) are widely dispersed throughout the
genomes of eukaryotes. Although nrEVEs are known to be involved in host antiviral …

Profile of Small RNAs, vDNA Forms and Viral Integrations in Late Chikungunya Virus Infection of Aedes albopictus Mosquitoes

M Marconcini, E Pischedda, V Houé, U Palatini… - Viruses, 2021 - mdpi.com
The Asian tiger mosquito Aedes albopictus is contributing to the (re)-emergence of
Chikungunya virus (CHIKV). To gain insights into the molecular underpinning of viral …