The vagus nerve represents the main component of the parasympathetic nervous system,
which oversees a vast array of crucial bodily functions, including control of mood, immune …

The monoamine hypothesis has been accepted as the most common hypothesis of major
depressive disorder (MDD) for a long period because of its simplicity and understandability …

The nervous system plays an important role in the regulation of epithelial homeostasis and
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Depression remains one of the most prevalent psychiatric disorders, with many patients not
responding adequately to available treatments. Chronic or early-life stress is one of the key …

Major depressive disorder (MDD) is prevalent. Although standards antidepressants are
more effective than placebo, up to 35% of patients do not respond to 4 or more conventional …

Adult hippocampal neurogenesis, a once unorthodox concept, has changed into one of the
most rapidly growing fields in neuroscience. The present report results from the ECNP …

Background The vagus nerve is involved in regulating immunity and resolving inflammation.
Current strategies aimed at modulating neuroinflammation and cognitive decline, in many …

In recent years, both major depression and antidepressant therapy have been linked to adult
hippocampal neurogenesis. The hippocampus is not a homogeneous brain area, and a …

VNS therapy was delivered to patients for the first time in 1988. After 25 years, insight in the
antiepileptic and antidepressant mechanism of action of VNS has grown steadily. The effects …