Targeted immunotherapy has improved patient survival in head and neck squamous cell
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …

Head and neck squamous cell carcinomas (HNSCCs) are amongst the most aggressive,
complex, and heterogeneous malignancies. The standard of care treatments for HNC …

The tumor microenvironment (TME) harbors a hidden universe of interactions that
profoundly shape the behavior of head and neck cancers (HNCs). HNCs are not merely …

Oral cavity carcinomas are the most frequent malignancies among head and neck
malignancies. Oral tumors include not only oral cancer cells with different potency and …

Background Metastatic disease remains the primary cause of death in patients with oral
squamous cell carcinoma (OSCC), especially those who use betel nut. The different steps of …

Although substantial progress has been made in cancer biology and treatment, the
prognosis of oral squamous cell carcinoma (OSCC) is still not satisfactory because of local …

Rationale: Platinum-based chemotherapy is commonly used for treating solid tumors, but
drug resistance often limits its effectiveness. Cancer-associated fibroblast (CAF)-derived …

Since its introduction in 1968, the TNM (tumor, node, metastasis) classification established
by the International Union Against Cancer has provided a consistent framework for staging …

Background Due to the expanding role of immune checkpoint inhibition in the treatment of
head and neck squamous cell carcinoma, understanding immunological processes in the …

Cancer-associated fibroblasts (CAFs) are abundant and heterogeneous in tumor
microenvironment (TME). Cross-talk between cancer cells and CAFs results in cancer …