[HTML][HTML] Co-suspension delivery technology in pressurized metered-dose inhalers for multi-drug dosing in the treatment of respiratory diseases

GT Ferguson, AJ Hickey, S Dwivedi - Respiratory medicine, 2018 - Elsevier
Technologies for long-term delivery of aerosol medications in asthma and chronic
obstructive pulmonary disease have improved over the past 2 decades with advancements …

Aerosol particle generation from solution-based pressurized metered dose inhalers: a technical overview of parameters that influence respiratory deposition

B Zhu, D Traini, P Young - Pharmaceutical Development and …, 2015 - Taylor & Francis
There are a multitude of formulation factors to consider when developing a solution-based
pressurized metered dose inhaler (pMDI). Evaluation of these variables and their …

Poly(amidoamine) Dendrimer–Doxorubicin Conjugates: In Vitro Characteristics and Pseudosolution Formulation in Pressurized Metered-Dose Inhalers

Q Zhong, SRP da Rocha - Molecular pharmaceutics, 2016 - ACS Publications
Lung cancers are the leading cause of cancer death for both men and women. A series of
PEGylated poly (amidoamine) dendrimer-based doxorubicin (DOX) nanocarriers (G3NH2 …

Influence of formulation factors on the aerosol performance of suspension and solution metered dose inhalers: a systematic approach

P Sheth, D Sandell, DS Conti, JT Holt, AJ Hickey… - The AAPS journal, 2017 - Springer
Metered dose inhalers (MDIs) are complex drug-device combination products widely used to
treat pulmonary disorders. The efficacy, driven by aerosol performance of the products …

Pressurized metered-dose inhalers

SRP da Rocha, B Bharatwaj, RS Heyder… - Pharmaceutical …, 2019 - taylorfrancis.com
Pressurized Metered-dose Inhalers (pMDIs) are complex drug-device combination products
that are widely used to treat lung diseases, and may also be advantageously employed to …

Polymeric nanocarriers for the regional and systemic delivery of therapeutics to and through the lungs

B Bharatwaj - 2012 - digitalcommons.wayne.edu
The lungs are considered as one of the fastest portals of entry to the bloodstream and oral
inhalation (OI) has long been accepted as the preferred mode of administration of …

[图书][B] Design of functional dendrimer nanocarriers and their formulations in propellant-based inhalers for pulmonary drug delivery

L Yang - 2014 - search.proquest.com
This Dissertation focuses on addressing two of the major challenges in developing
pressurized metered dose inhalers for pulmonary drug/gene delivery to and through the …

[PDF][PDF] Hydrofluoroalkane-philicity: Excipient Screening for Pressurized Metered Dose Inhaler Formulations

SRP da Rocha, DS Conti - researchgate.net
Hydrofluoroalkane-philicity: Excipient Screening for Pressurized Metered Dose Inhaler
Formulations Page 1 143 Respiratory Drug Delivery Europe 2017 – da Rocha and Conti …

[图书][B] Dendrimer nanoconjugates and their oral inhalation formulations for lung cancer therapy

Q Zhong - 2016 - search.proquest.com
Lung cancers are leading cause of cancer death for both men and women in the world.
Lungs are also one of the primary organs to which almost all cancer can spread …

The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical …

R Telford - 2013 - bradscholars.brad.ac.uk
Active Pharmaceutical Ingredients (APIs) are frequently prepared for delivery to the lung for
local topical treatment of diseases such as Chronic Obstructive Pulmonary Disease (COPD) …