The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
CD Arvanitis, GB Ferraro, RK Jain - Nature Reviews Cancer, 2020 - nature.com
For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …
Tumor targeting via EPR: Strategies to enhance patient responses
The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …
Virtual histological staining of unlabelled tissue-autofluorescence images via deep learning
The histological analysis of tissue samples, widely used for disease diagnosis, involves
lengthy and laborious tissue preparation. Here, we show that a convolutional neural network …
lengthy and laborious tissue preparation. Here, we show that a convolutional neural network …
[HTML][HTML] Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
[HTML][HTML] Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …
[HTML][HTML] Reengineering the physical microenvironment of tumors to improve drug delivery and efficacy: from mathematical modeling to bench to bedside
Physical forces have a crucial role in tumor progression and cancer treatment. The
application of principles of engineering and physical sciences to oncology has provided …
application of principles of engineering and physical sciences to oncology has provided …
[HTML][HTML] Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
RK Jain - Cancer cell, 2014 - cell.com
Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment.
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …
Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens
For the 1.7 million patients per year in the US who receive a new cancer diagnosis,
treatment decisions are largely based on histopathological specimen examinations …
treatment decisions are largely based on histopathological specimen examinations …
Through-skull fluorescence imaging of the brain in a new near-infrared window
To date, brain imaging has largely relied on X-ray computed tomography and magnetic
resonance angiography, with their limited spatial resolution and long scanning times …
resonance angiography, with their limited spatial resolution and long scanning times …
Optical coherence tomography based angiography
Optical coherence tomography (OCT)-based angiography (OCTA) provides in vivo, three-
dimensional vascular information by the use of flowing red blood cells as intrinsic contrast …
dimensional vascular information by the use of flowing red blood cells as intrinsic contrast …