We currently have a poor understanding of the pathogenesis of neurodevelopmental
disorders, owing to the fact that postmortem and imaging studies can only measure the …

Over a decade of schizophrenia research using human induced pluripotent stem cell (iPSC)-
derived neural models has provided substantial data describing neurobiological …

In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak
and its link to microcephaly and other neurological conditions, we performed a drug …

We investigated whether extracellular RNA communication, which is a recently discovered
mode of intercellular communication that is involved in a variety of important biological …

Forebrain precursor cells are dynamic during early brain development, yet the underlying
molecular changes remain elusive. We observed major differences in transcriptional …

Protein synthesis in eukaryotic cells is a complex, multi-step and tightly regulated process.
Translation initiation, the rate limiting step in protein synthesis, is dependent on the activity of …

Induced pluripotent stem cells (iPSCs) are terminally differentiated somatic cells that
differentiate into various cell types. iPSCs are expected to be used for disease modeling and …

Modulation of transcription, either synthetic activation or repression, via dCas9-fusion
proteins is a relatively new methodology with the potential to facilitate high-throughput up-or …

The measurement of gene expression in postmortem brain is an important tool for
understanding the pathogenesis of serious psychiatric disorders. We hypothesized that …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder caused by
genetic or environmental perturbations during early development. Diagnoses are dependent …