Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface
In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
The airways of patients with cystic fibrosis (CF) are nearly always infected with many
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …
The role of bacterial biofilms in chronic infections
T Bjarnsholt - Apmis, 2013 - Wiley Online Library
Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …
100 years. These infections killed millions of people in previous centuries, but they have …
The distribution of bacterial doubling times in the wild
Generation time varies widely across organisms and is an important factor in the life cycle,
life history and evolution of organisms. Although the doubling time (DT) has been estimated …
life history and evolution of organisms. Although the doubling time (DT) has been estimated …
Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
Little is known about how within-host evolution compares between genotypically different
strains of the same pathogenic species. We sequenced the whole genomes of 474 …
strains of the same pathogenic species. We sequenced the whole genomes of 474 …
Bacterial biofilms predominate in both acute and chronic human lung infections
Background A basic paradigm of human infection is that acute bacterial disease is caused
by fast growing planktonic bacteria while chronic infections are caused by slow-growing …
by fast growing planktonic bacteria while chronic infections are caused by slow-growing …
Antibiotic resistance of bacterial biofilms
A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix
consisting of polysaccharide, protein and DNA. Bacterial biofilms cause chronic infections …
consisting of polysaccharide, protein and DNA. Bacterial biofilms cause chronic infections …
Applying insights from biofilm biology to drug development—can a new approach be developed?
Most of the research on bacterial pathogenesis has focused on acute infections, but much
less is known about the pathogenesis of infections caused by bacteria that grow as …
less is known about the pathogenesis of infections caused by bacteria that grow as …
Pseudomonas Aeruginosa Biofilms in Cystic fibrosis
NH⊘ iby, O Ciofu, T Bjarnsholt - Future microbiology, 2010 - Taylor & Francis
The persistence of chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF)
patients is due to biofilm-growing mucoid (alginate-producing) strains. A biofilm is a …
patients is due to biofilm-growing mucoid (alginate-producing) strains. A biofilm is a …
Evolving concepts in biofilm infections
L Hall‐Stoodley, P Stoodley - Cellular microbiology, 2009 - Wiley Online Library
Several pathogens associated with chronic infections, including Pseudomonas aeruginosa
in cystic fibrosis pneumonia, Haemophilus influenzae and Streptococcus pneumoniae in …
in cystic fibrosis pneumonia, Haemophilus influenzae and Streptococcus pneumoniae in …