In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the
central and peripheral nervous systems. Other than the previously established signaling …

Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …

Introduction Metabolite, lipid, and lipoprotein lipid profiling can provide novel insights into
mechanisms underlying incident dementia and Alzheimer's disease. Methods We studied …

It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …

Reduction and oxidation reactions are essential for biochemical processes. They are part of
metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second …

Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in
many physiological processes. For example, the spatial and temporal organization of Ca2+ …

Alzheimer's disease (AD) is a chronic dysfunction of neurons in the brain leading to
dementia. It is characterized by gradual mental failure, abnormal cognitive functioning …

Circular RNAs (circRNAs) are abundant in mammalian brain and some show age-
dependent expression patterns. Here, we report that circGRIA1, a conserved circRNA …

Significance: Oxidative stress increases in the brain with aging and neurodegenerative
diseases. Previous work emphasized irreversible oxidative damage in relation to cognitive …