Biological cells are well known to respond to a multitude of chemical signals. In the nervous
system, chemical signaling has been shown to be crucially involved in development, normal …

The development of the nervous system has so far, to a large extent, been considered in the
context of biochemistry, molecular biology and genetics. However, there is growing …

Neurons and neural stem cells are sensitive to their mechanical and topographical
environment, and cell–substrate binding contributes to this sensitivity to activate signaling …

Establishing extracellular milieus to stimulate neuronal regeneration is a critical need in
neuronal tissue engineering. Many studies have used a soluble factor (such as nerve growth …

Elongation of nerve fibers intuitively occurs throughout mammalian development, and is
synchronized with expansion of the growing body. While most tissue systems enlarge …

The central feature of peripheral motor axons is their remarkable lengths as they project from
a motor neuron residing in the spinal cord to distant target muscle. However, current in vitro …

In this paper a neuronal membrane bioreactor was developed as platform for the in vitro
reconstruction of a neuronal network with defined functional, geometric and …

Axons in the developing nervous system are directed via guidance cues, whose expression
varies both spatially and temporally, to create functional neural circuits. Existing methods to …

Neuronal mechanobiology plays a vital function in brain development and homeostasis with
an essential role in neuronal maturation, pathfinding, and differentiation but is also crucial …

Filopodia are 5-10 μm long processes that elongate by actin polymerization, and promote
axon growth and guidance by exerting mechanical tension and by molecular signaling …