Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Immune checkpoint blockade (ICB) therapies have achieved remarkable clinical responses
in patients with many different types of cancer; however, most patients who receive ICB …

Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-
ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable …

Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-
derived nucleic acids and respond with rapid and massive production of type I interferon …

Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are
emerging as an essential antitumor component based on their ability to foster T cell …

Impaired type I interferons (IFNs) may cause immune deficiency in tumours. Current
supplementary IFN therapy partially restores anticancer immunity but simultaneously …

The interferons (IFNs) are a family of cytokines that protect against disease by direct effects
on target cells and by activating immune responses. The production and actions of IFNs are …

Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this
Review, we discuss accumulating evidence indicating that type I IFNs produced by …

Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the
production of type I interferons (IFNs). pDCs promote antiviral immune responses and have …