Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

Associations of diet and physical activity with risk for gestational diabetes mellitus: a systematic review and meta-analysis

J Mijatovic-Vukas, L Capling, S Cheng, E Stamatakis… - Nutrients, 2018 - mdpi.com
Rising rates of gestational diabetes mellitus (GDM) and related complications have
prompted calls to identify potentially modifiable risk factors that are associated with …

Effects of maternal obesity on placental function and fetal development

KR Howell, TL Powell - Reproduction (Cambridge, England), 2016 - pmc.ncbi.nlm.nih.gov
Obesity has reached epidemic proportions and pregnancies in obese mothers have
increased risk for complications including gestational diabetes, hypertensive disorders …

Placental function in maternal obesity

AC Kelly, TL Powell, T Jansson - Clinical Science, 2020 - portlandpress.com
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta‐analysis

L Gaudet, ZM Ferraro, SW Wen… - BioMed research …, 2014 - Wiley Online Library
Objective. To determine a precise estimate for the contribution of maternal obesity to
macrosomia. Data Sources. The search strategy included database searches in 2011 of …

Placental responses to changes in the maternal environment determine fetal growth

KG Dimasuay, P Boeuf, TL Powell… - Frontiers in physiology, 2016 - frontiersin.org
Placental responses to maternal perturbations are complex and remain poorly understood.
Altered maternal environment during pregnancy such as hypoxia, stress, obesity, diabetes …

The association between pregnancy weight gain and birthweight: a within-family comparison

DS Ludwig, J Currie - The Lancet, 2010 - thelancet.com
Background Excessive weight gain during pregnancy seems to increase birthweight and the
offspring's risk of obesity later in life. However, this association might be confounded by …

Maternal obesity and diabetes mellitus as risk factors for congenital heart disease in the offspring

E Helle, JR Priest - Journal of the American Heart Association, 2020 - Am Heart Assoc
Congenital heart disease (CHD) is the most common anatomical malformation occurring live‐
born infants and an increasing cause of morbidity and mortality across the lifespan and …

Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies

N Jansson, FJ Rosario, F Gaccioli… - The Journal of …, 2013 - academic.oup.com
Context: Babies of obese women are often large at birth, which is associated with perinatal
complications and metabolic syndrome later in life. The mechanisms linking maternal …

[HTML][HTML] High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice

HN Jones, LA Woollett, N Barbour, PD Prasad… - The FASEB …, 2009 - ncbi.nlm.nih.gov
Maternal overweight and obesity in pregnancy often result in fetal overgrowth, which
increases the risk for the baby to develop metabolic syndrome later in life. However, the …