Metabolism and colorectal cancer
Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …
Targeting AhR as a novel therapeutic modality against inflammatory diseases
For decades, activation of Aryl Hydrocarbon Receptor (AhR) was excluded from
consideration as a therapeutic approach due to the potential toxic effects of AhR ligands and …
consideration as a therapeutic approach due to the potential toxic effects of AhR ligands and …
[HTML][HTML] Bisphenol P exposure in C57BL/6 mice caused gut microbiota dysbiosis and induced intestinal barrier disruption via LPS/TLR4/NF-κB signaling pathway
N Ma, D Ma, X Liu, L Zhao, L Ma, D Ma, S Dong - Environment International, 2023 - Elsevier
Despite being one of the most world's widely used and mass-produced compounds,
bisphenol A (BPA) has a wide range of toxic effects. Bisphenol P (BPP), an alternative to …
bisphenol A (BPA) has a wide range of toxic effects. Bisphenol P (BPP), an alternative to …
[HTML][HTML] Unraveling the genomic background of resilience based on variability in milk yield and milk production levels in North American Holstein cattle through …
Breeding more resilient animals will benefit the dairy cattle industry in the long term,
especially as global climate changes become more severe. Previous studies have reported …
especially as global climate changes become more severe. Previous studies have reported …
Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation
Y Chen, Y Wang, Y Fu, Y Yin, K Xu - Cell & Bioscience, 2023 - Springer
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that …
tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that …
Tumor-suppressive functions of the aryl hydrocarbon receptor (AhR) and AhR as a therapeutic target in cancer
DJ Elson, SK Kolluri - Biology, 2023 - mdpi.com
Simple Summary Cancer is driven by the excessive activity of growth-promoting genes and
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19
M Essex, B Millet Pascual-Leone, U Löber… - npj Biofilms and …, 2024 - nature.com
The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis
that disease progression and inflammatory responses associate with alterations in the …
that disease progression and inflammatory responses associate with alterations in the …
Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs
F Congues, P Wang, J Lee, D Lin, A Shahid… - Biochemical …, 2024 - Elsevier
The skin, lung, and gut are important barrier organs that control how the body reacts to
environmental stressors such as ultraviolet (UV) radiation, air pollutants, dietary …
environmental stressors such as ultraviolet (UV) radiation, air pollutants, dietary …
Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal …
G Vázquez-Gómez, J Petráš, Z Dvořák… - Biochemical …, 2023 - Elsevier
Both aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) belong among key
regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a …
regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a …
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Gut microbiota regulates various aspects of human physiology by producing metabolites,
metabolizing enzymes, and toxins. Many studies have linked microbiota with human health …
metabolizing enzymes, and toxins. Many studies have linked microbiota with human health …