The inter-α-trypsin inhibitor family: Versatile molecules in biology and pathology
Inter-α-trypsin inhibitor (IαI) family members are ancient and unique molecules that have
evolved over several hundred million years of vertebrate evolution. IαI is a complex …
evolved over several hundred million years of vertebrate evolution. IαI is a complex …
[HTML][HTML] The role of fibrosis in osteoarthritis progression
YA Rim, JH Ju - Life, 2020 - mdpi.com
Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics
include cartilage degeneration and synovial membrane inflammation. These changes in the …
include cartilage degeneration and synovial membrane inflammation. These changes in the …
[HTML][HTML] Mutational landscape of basal cell carcinomas by whole-exome sequencing
SS Jayaraman, DJ Rayhan, S Hazany… - Journal of Investigative …, 2014 - Elsevier
Recent advances in sequencing technology allow genome-scale approaches to cancer
mutation discovery. Such data-intensive methods have been applied to cutaneous …
mutation discovery. Such data-intensive methods have been applied to cutaneous …
Genetic architecture of colorectal cancer
U Peters, S Bien, N Zubair - Gut, 2015 - gut.bmj.com
Colorectal cancer (CRC) is a complex disease that develops as a consequence of both
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …
Nanoparticle biomolecular corona-based enrichment of plasma glycoproteins for N-glycan profiling and application in biomarker discovery
Biomolecular corona formation has emerged as a recurring and important phenomenon in
nanomedicine that has been investigated for potential applications in disease diagnosis. In …
nanomedicine that has been investigated for potential applications in disease diagnosis. In …
[HTML][HTML] Extracellular vesicles mediate mesenchymal stromal cell-dependent regulation of B cell PI3K-AKT signaling pathway and actin cytoskeleton
Mesenchymal stromal cells (MSCs) are adult, multipotent cells of mesodermal origin
representing the progenitors of all stromal tissues. MSCs possess significant and broad …
representing the progenitors of all stromal tissues. MSCs possess significant and broad …
[HTML][HTML] Whole exome sequencing reveals inherited and de novo variants in autism spectrum disorder: a trio study from Saudi families
B Al-Mubarak, M Abouelhoda, A Omar, H AlDhalaan… - Scientific reports, 2017 - nature.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with genetic
and clinical heterogeneity. The interplay of de novo and inherited rare variants has been …
and clinical heterogeneity. The interplay of de novo and inherited rare variants has been …
Illuminating radiogenomic characteristics of glioblastoma multiforme through integration of MR imaging, messenger RNA expression, and DNA copy number variation
Purpose To perform a multilevel radiogenomics study to elucidate the glioblastoma
multiforme (GBM) magnetic resonance (MR) imaging radiogenomic signatures resulting …
multiforme (GBM) magnetic resonance (MR) imaging radiogenomic signatures resulting …
[HTML][HTML] Increased peri-ductal collagen micro-organization may contribute to raised mammographic density
JC McConnell, OV O'Connell, K Brennan… - Breast Cancer …, 2016 - Springer
Background High mammographic density is a therapeutically modifiable risk factor for breast
cancer. Although mammographic density is correlated with the relative abundance of …
cancer. Although mammographic density is correlated with the relative abundance of …
[HTML][HTML] Proteomics and metabolomics profiling of platelets and plasma mediators of thrombo-inflammation in gestational hypertension and preeclampsia
LGN de Almeida, D Young, L Chow, J Nicholas, A Lee… - Cells, 2022 - mdpi.com
Platelets may be pivotal mediators of the thrombotic and coagulopathic complications of
preeclampsia (PE), linking inflammation and thrombosis with endothelial and vascular …
preeclampsia (PE), linking inflammation and thrombosis with endothelial and vascular …