Nanomaterial delivery systems for mRNA vaccines
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …
development of lipid nanoparticle delivery systems that not only efficiently express the …
[HTML][HTML] Dosing extracellular vesicles
D Gupta, AM Zickler, S El Andaloussi - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) are natural nanoparticles containing biologically active
molecules. They are important mediators of intercellular communication and can be …
molecules. They are important mediators of intercellular communication and can be …
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells
assembles large complexes called inflammasomes, which activate inflammatory caspases …
assembles large complexes called inflammasomes, which activate inflammatory caspases …
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a
severe respiratory disease associated with more than 2468 human infections and over 851 …
severe respiratory disease associated with more than 2468 human infections and over 851 …
[HTML][HTML] Psychedelics and neuroplasticity: a systematic review unraveling the biological underpinnings of psychedelics
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that
underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive …
underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive …
The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond
Epilepsy is one of the most common and disabling chronic neurological disorders.
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors
Adoptive cell therapy (ACT) has proven to be highly effective in treating blood cancers, but
traditional approaches to ACT are poorly effective in treating solid tumors observed …
traditional approaches to ACT are poorly effective in treating solid tumors observed …
In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
NN Parayath, SB Stephan, AL Koehne… - Nature …, 2020 - nature.com
Engineering chimeric antigen receptors (CAR) or T cell receptors (TCR) helps create
disease-specific T cells for targeted therapy, but the cost and rigor associated with …
disease-specific T cells for targeted therapy, but the cost and rigor associated with …
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
J Bonaventura, S Lam, M Carlton, MA Boehm… - Molecular …, 2021 - nature.com
Ketamine, a racemic mixture of (S)-ketamine and (R)-ketamine enantiomers, has been used
as an anesthetic, analgesic and more recently, as an antidepressant. However, ketamine …
as an anesthetic, analgesic and more recently, as an antidepressant. However, ketamine …