DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

5–Hydroxymethylcytosine (hmC) was recently detected as the sixth base in mammalian
tissue at so far controversial levels. The function of the modified base is currently unknown …

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …

Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based
profiling methods. The four most frequently used sequencing-based technologies are the …

The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA
methylation patterns in a particular genome context is not well understood. Here, we …

Abstract The overall 5-methylcytosine (m5C) content of DNA from normal tissues varies
considerably in a tissue-specific manner. By high-performance liquid chromatography, we …

Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also
over larger genomic regions. In most human tissues, the vast majority of the genome is …

Mind over matter: LC‐MS has allowed the amount of the post‐replicatively formed DNA base
5‐hydroxymethylcytosine (see picture; left) to be quantified in brain tissue. The nucleoside is …

We investigated whether ancestral liver damage leads to heritable reprogramming of
hepatic wound healing in male rats. We found that a history of liver damage corresponds …