Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …

Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Melanosomes are tissue-specific lysosome-related organelles of pigment cells in which
melanins are synthesized and stored. Analyses of the trafficking and fate of melanosomal …

Albinism is a pigment disorder affecting eye, skin and/or hair. Patients usually have
decreased melanin in affected tissues and suffer from severe visual abnormalities, including …

Cellular membrane homoeostasis is maintained via a tightly regulated membrane and cargo
flow between organelles of the endocytic and secretory pathways. Adaptor protein …

Genetic disorders affecting biogenesis and transport of lysosome-related organelles are
heterogeneous diseases frequently associated with albinism. We studied a patient with …

Unique functions of specialised cells such as those of the immune and haemostasis
systems, skin, blood vessels, lung, and bone require specialised compartments, collectively …

Neurodevelopmental disorders such as intellectual disability, autism spectrum disorder and
schizophrenia lack precise boundaries in their clinical definitions, epidemiology, genetics …

Copper is a cofactor for many cellular enzymes and transporters. It can be loaded onto
secreted and endomembrane cuproproteins by translocation from the cytosol into …