Metalloproteinases were first identified as collagen cleaving enzymes and are now
appreciated to play important roles in a wide variety of biological processes. The aberrant …

Cartilage is a connective tissue in the skeletal system and has limited regeneration ability
and unique biomechanical reactivity. The growth and development of cartilage can be …

The pathogenesis of preeclampsia, a pregnancy-related disease, is not completely
understood. The primary cilium transduces a diverse array of signaling pathways important …

Primary cilia and associated intraflagellar transport are essential for skeletal development,
joint homeostasis, and the response to mechanical stimuli, although the mechanisms remain …

In vertebrate, the nucleus pulposus (NP), which is an essential component of the
intervertebral disk, is constantly impacted by fluid shear stress (FSS); however, molecular …

The primary cilium is an organelle involved in cellular signalling. Mutations affecting proteins
involved in cilia assembly or function result in diseases known as ciliopathies, which cause …

Objective Mechanical and biologic cues drive cellular signaling in cartilage development,
health, and disease. Primary cilia proteins, which are implicated in the transduction of …

Primary cilia are non-motile, microtubule-based sensory organelle present in most
vertebrate cells with a fundamental role in the modulation of organismal development …

In recent years, the incidence of teratospermia has been increasing, and it has become a
very important factor leading to male infertility. The research on the molecular mechanism of …

Articular cartilage (AC) is essential for body movement but is highly susceptible to
degenerative diseases and has poor self‐repair capacity. To improve current subpar …