Trauma remains a leading cause of death worldwide, and most early preventable deaths in
both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm …

One quarter of patients suffering from acute critical illness such as severe trauma, sepsis,
myocardial infarction (MI) or post cardiac arrest syndrome (PCAS) develop severe …

Abstracts Background The number of studies measuring breakdown products of the
glycocalyx in plasma has increased rapidly during the past decade. The purpose of the …

Polytrauma (PT) is frequently associated with hemorrhagic shock (HS), which increases
morbidity and mortality. Although various aspects of HS have been addressed in PT …

Background: Trauma patients are vulnerable to coagulopathy and inflammatory dysfunction
associated with endotheliopathy of trauma (EoT). In vitro evidence has suggested that …

There is no standard definition for trauma-induced coagulopathy (TIC). However, it could be
defined as an abnormal hemostatic response secondary to trauma. The terms “early TIC” …

The recognition and management of life-threatening hemorrhage in the polytrauma patient
poses several challenges to prehospital rescue personnel and hospital providers. First …

Hypercoagulability can occur after severe tissue injury, that is likely related to tissue factor
exposure and impaired endothelial release of tissue plasminogen activator (tPA). In contrast …

Background Endothelial glycocalyx breakdown elicits syndecan-1 shedding and
endotheliopathy of trauma (EoT). We hypothesized that a cutoff syndecan-1 level can …

Objective To conduct a narrative review of the current literature in reference to the structure
and function of the endothelial glycocalyx (EG) and its contribution to the pathophysiology of …