Recently Discovered Secondary Metabolites from Streptomyces Species
HJ Lacey, PJ Rutledge - Molecules, 2022 - mdpi.com
The Streptomyces genus has been a rich source of bioactive natural products, medicinal
chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the …
chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the …
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)
F Maglangit, Y Yu, H Deng - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to the second quarter of 2020 Threat or treat? While pathogenic bacteria pose
significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat …
significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat …
Molecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive …
Mycobacterial pathogens present a significant challenge to disease control efforts globally
due to their inherent resistance to multiple antibiotics. The rise of drug-resistant strains of …
due to their inherent resistance to multiple antibiotics. The rise of drug-resistant strains of …
Strasseriolides display in vitro and in vivo activity against trypanosomal parasites and cause morphological and size defects in Trypanosoma cruzi
C Bosch-Navarrete, G Pérez-Moreno… - PLOS Neglected …, 2023 - journals.plos.org
Neglected diseases caused by kinetoplastid parasites are a health burden in tropical and
subtropical countries. The need to create safe and effective medicines to improve treatment …
subtropical countries. The need to create safe and effective medicines to improve treatment …
Characterization of Streptomyces Species and Validation of Antimicrobial Activity of Their Metabolites through Molecular Docking
Finding new antibacterial agents from natural products is urgently necessary to address the
growing cases of antibiotic-resistant pathogens. Actinomycetes are regarded as an excellent …
growing cases of antibiotic-resistant pathogens. Actinomycetes are regarded as an excellent …
A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are structurally
complex natural products with diverse bioactivities. Here we report discovery of a RiPP …
complex natural products with diverse bioactivities. Here we report discovery of a RiPP …
Deletion of the accramycin pathway-specific regulatory gene accJ activates the production of unrelated polyketide metabolites
The manipulation of regulatory genes has been employed to awaken cryptic metabolites in
Streptomyces. Of particular interest in recent years is the effect of disruption of a pathway …
Streptomyces. Of particular interest in recent years is the effect of disruption of a pathway …
Discovery of New Antibacterial Accramycins from a Genetic Variant of the Soil Bacterium, Streptomyces sp. MA37
Continued mining of natural products from the strain Streptomyces sp. MA37 in our
laboratory led to the discovery of a minor specialized metabolite (SM) called accramycin A …
laboratory led to the discovery of a minor specialized metabolite (SM) called accramycin A …
Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores including New Dehydroxylated …
In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella
speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners …
speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners …
Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37
Four compounds (1–4) were isolated from the extracts of Streptomyces sp. CT37 using
bioassay in conjunction with mass spectrometric molecular networking (MN) driven isolation …
bioassay in conjunction with mass spectrometric molecular networking (MN) driven isolation …