Sox transcription factors play many diverse roles during development, including regulating
stem cell states, directing differentiation, and influencing the local chromatin landscape. Of …

Background SOX11 is a transcription factor proposed to play a role in brain development.
The relevance of SOX11 to human developmental disorders was suggested by a recent …

SOX4, together with SOX11 and SOX12, forms group C of SRY-related (SOX) transcription
factors. They play key roles, often in redundancy, in multiple developmental pathways …

Glaucoma and other optic neuropathies result in optic nerve degeneration and the loss of
retinal ganglion cells (RGCs) through complex signaling pathways. Although the …

Background DNA methylation and its perturbations are an established attribute to a wide
spectrum of phenotypic variations and disease conditions. Indian traditional system …

To address how conserved DNA methylation-based epigenetic aging is in diverse branches
of the tree of life, we generated DNA methylation data from African clawed frogs (Xenopus …

What pathways specify retinal ganglion cell (RGC) fate in the developing retina? Here we
report on mechanisms by which a molecular pathway involving Sox4/Sox11 is required for …

Mutations in PRDM15 lead to a syndromic form of holoprosencephaly (HPE) known as the
Galloway–Mowat syndrome (GAMOS). While a connection between PRDM15, a zinc finger …

Background The impaired blood supply to the bones is an important pathological feature of
steroid-induced osteonecrosis of the femoral head (SIONFH). Danshen is a Chinese herb …

There is increasing concern about the health effects of pesticides that pollute natural waters.
In particular, the use of neonicotinoids, such as thiacloprid (THD), is causing unease. THD is …