Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple
lesions. The main manifestations include dryness of the mouth and eyes, along with …

Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …

The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …

In humans, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is highly
infective, often causes severe acute and/or long-term illness, and elicits a high rate of …

Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …

Cytokines are important molecules that regulate the ontogeny and function of the immune
system. They are small secreted proteins usually produced upon activation of cells of the …

Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and
adaptive immunity. They play important roles in host defense, but excessive immune …