Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This
simple reaction rapidly and irreversibly sets the cell up for division. Even though the core …

Oocyte developmental competence is the ability of the mature oocyte to be fertilized and
subsequently drive early embryo development. Developmental competence is acquired by …

The atypical AGC kinase Greatwall (Gwl) mediates a pathway that prevents the precocious
removal of phosphorylations added to target proteins by M phase-promoting factor (MPF); …

Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in
mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) …

Inhibition of cyclin-dependent kinase 1 (CDK1) by phosphorylation is a key regulatory
mechanism for both the unperturbed cell cycle and the DNA damage checkpoint. Although …

The earliest stages of animal development are largely controlled by changes in protein
phosphorylation mediated by signaling pathways and cyclin-dependent kinases. In order to …

In the adult mammalian brain, most neural stem cells (NSCs) are held in a reversible state of
quiescence, which is essential to avoid NSC exhaustion and determine the appropriate …

Background The cell cycle is tightly regulated by checkpoints, which play a vital role in
controlling its progression and timing. Cancer cells exploit the G2/M checkpoint, which …

MIG6 is an important tumor suppressor that binds to and negatively regulates epidermal
growth factor receptor (EGFR). Here, we report an EGFR-independent function for MIG6 as …

Cyclin-dependent kinases (CDKs) require the binding to a regulatory subunit to acquire
enzymatic activity, and cyclins are the canonical CDK activators. However, there are specific …