Among the popular animal models of Parkinson's disease (PD) commonly used in research
are those that employ neurotoxins, especially 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine …

Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

The mechanistic influences of dopamine (DA) signaling and impact on motor function are
nearly always interpreted from changes in nigrostriatal neuron terminals in striatum. This is a …

Although glial cell line-derived neurotrophic factor (GDNF) showed efficacy in preclinical
and early clinical studies to alleviate parkinsonian signs in Parkinson's disease (PD), later …

Depression is a debilitating mental disorder that causes a persistent feeling of sadness and
loss of interest. Approximately 280 million individuals worldwide suffer from depression by …

Identifying neurobiological mechanisms of aging-related parkinsonism, and lifestyle
interventions that mitigate them, remain critical knowledge gaps. No aging study, from rodent …

目的: 利用生物信息学分析帕金森病人黑质基因表达谱, 为进一步帕金森病研究提供研究方向.
方法: 在Gene Expression Omnibus (GEO) 数据库中使用“帕金森病”,“组织”,“表达谱” …

Einleitung: Das Parkinson-Syndrom ist eine der häufigsten neurodegenerativen
Erkrankungen und es wird geschätzt, dass sich die Anzahl der Patientinnen und Patienten …

The maintenance of physical function throughout the lifespan is a hallmark of successful
aging. However, vulnerability to motor impairment during aging is evident in a substantial …

Parkinson's Disease (PD) results in motor deficits which are symptomatically treated with
levodopa (L-DOPA). However, chronic use of L-DOPA inevitably leads to the development of …