Spider venom: components, modes of action, and novel strategies in transcriptomic and proteomic analyses

N Langenegger, W Nentwig, L Kuhn-Nentwig - Toxins, 2019 - mdpi.com
This review gives an overview on the development of research on spider venoms with a
focus on structure and function of venom components and techniques of analysis. Major …

Venom systems as models for studying the origin and regulation of evolutionary novelties

G Zancolli, NR Casewell - Molecular Biology and Evolution, 2020 - academic.oup.com
A central goal in biology is to determine the ways in which evolution repeats itself. One of the
most remarkable examples in nature of convergent evolutionary novelty is animal venom …

Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity

X Ye, C He, Y Yang, YH Sun, S Xiong… - Genome …, 2023 - genome.cshlp.org
Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …

The evolutionary dynamics of venom toxins made by insects and other animals

AA Walker - Biochemical Society Transactions, 2020 - portlandpress.com
Animal venoms are recognised as unique biological systems in which to study molecular
evolution. Venom use has evolved numerous times among the insects, and insects today …

[PDF][PDF] The Tetragnatha kauaiensis Genome Sheds Light on the Origins of Genomic Novelty in Spiders

J Cerca, EE Armstrong, J Vizueta… - Genome Biology and …, 2021 - academic.oup.com
Spiders (Araneae) have a diverse spectrum of morphologies, behaviors, and physiologies.
Attempts to understand the genomic-basis of this diversity are often hindered by their large …

De Novo Transcriptome Analysis of the Venom of Latrodectus geometricus with the Discovery of an Insect-Selective Na Channel Modulator

P Khamtorn, S Peigneur, FG Amorim, L Quinton… - Molecules, 2021 - mdpi.com
The brown widow spider, Latrodectus geometricus, is a predator of a variety of agricultural
insects and is also hazardous for humans. Its venom is a true pharmacopeia representing …

Protein composition and associated material properties of cobweb spiders' gumfoot glue droplets

NA Ayoub, K Friend, T Clarke, R Baker… - Integrative and …, 2021 - academic.oup.com
The origin of aggregate silk glands and their production of wet adhesive silks is considered
a key innovation of the Araneoidea, a superfamily of spiders that build orb-webs and …

Genomic and transcriptomic analyses support a silk gland origin of spider venom glands

B Zhu, P Jin, Y Zhang, Y Shen, W Wang, S Li - BMC biology, 2023 - Springer
Background Spiders comprise a hyperdiverse lineage of predators with venom systems, yet
the origin of functionally novel spider venom glands remains unclear. Previous studies have …

The origin and evolution of antistasin-like proteins in leeches (Hirudinida, Clitellata)

RE Iwama, M Tessler, ME Siddall… - Genome biology and …, 2021 - academic.oup.com
Bloodfeeding is employed by many parasitic animals and requires specific innovations for
efficient feeding. Some of these innovations are molecular features that are related to the …

Venom gland organogenesis in the common house spider

A Hassan, G Blakeley, AP McGregor, G Zancolli - Scientific Reports, 2024 - nature.com
Venom is a remarkable innovation found across the animal kingdom, yet the evolutionary
origins of venom systems in various groups, including spiders, remain enigmatic. Here, we …