Anti-PSMA CAR-engineered NK-92 cells: an off-the-shelf cell therapy for prostate cancer

IM Montagner, A Penna, G Fracasso, D Carpanese… - Cells, 2020 - mdpi.com
Prostate cancer (PCa) has become the most common cancer among males in Europe and
the USA. Adoptive immunotherapy appears a promising strategy to control the advanced …

Engineering for success: approaches to improve chimeric antigen receptor T cell therapy for solid tumors

M Mata, S Gottschalk - Drugs, 2019 - Springer
While impressive clinical responses have been observed using chimeric antigen receptor
(CAR) T cells targeting CD19+ hematologic malignancies, limited clinical benefit has been …

Combinatorial suicide gene strategies for the safety of cell therapies

C Falcon, L Smith, M Al-Obaidi… - Frontiers in …, 2022 - frontiersin.org
Gene-modified cellular therapies carry inherent risks of severe and potentially fatal adverse
events, including the expansion of alloreactive cells or malignant transformation due to …

Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses

J Makoukji, F Saadeh, KA Mansour… - Annals of Clinical …, 2018 - Wiley Online Library
Abstract Objective Neuronal Ceroid Lipofuscinoses (NCL) are fatal inherited
neurodegenerative diseases with established neuronal cell death and increased ceramide …

OPEN ACCESS EDITED BY

S Moyce, AF Abraido-Lanza… - Public health and …, 2024 - books.google.com
Method: Between September and December 2020, a health questionnaire was administered
via telephone to n= 250 migrants from Venezuela. Descriptive statistics summarized the …

[PDF][PDF] Absence of p21 Expression Sensitizes iPSCs to iCaspase9 Induced Apoptosis While Not Impacting Ability to Participate in Exogenous Cartilage Repair

L Larijani - 2022 - prism.ucalgary.ca
Absence of p21 Expression Sensitizes iPSCs to iCaspase9 Induced Apoptosis While Not
Impacting Ability to Participate in Exogenou Page 1 University of Calgary PRISM Repository …

Safety Switches Used for Cellular Therapies

L Smith, A Di Stasi - Gene and Cellular Immunotherapy for Cancer, 2022 - Springer
Gene and cellular immunotherapy is rapidly changing the way we treat cancer. But,
unfortunately, these promising therapies can result in serious, sometimes fatal …

Compound for inhibiting cell death

S Krautwald, U Kunzendorf - US Patent App. 17/641,670, 2022 - Google Patents
The present invention relates to the field of diseases or conditions that involve a pathologic
level of RIPK1-dependent cell death. Specifically, the present invention refers to the use of …

Chimeric antigen receptors for direct and indirect targeting of fibronectin-positive tumors

S Gottschalk, J Wagner, TI Shaw… - US Patent App. 17 …, 2022 - Google Patents
AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O ([C@ H] 1C
[C@@](O)(CC= 2C (O)= C3C (= O) C= 4C= CC= C (C= 4C (= O) C3= C (O) C= 21) OC) C …