Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

After they are born and differentiate, neurons break their previous symmetry, dramatically
change their shape, and establish two structurally and functionally distinct compartments …

▪ Abstract The guidance of axons during the establishment of the nervous system is
mediated by a variety of extracellular cues that govern cytoskeletal dynamics in axonal …

Regeneration in the CNS is blocked by many different growth inhibitory proteins. To foster
regeneration, we have investigated a strategy to block the neuronal response to growth …

Rho GTPases have been implicated in diverse cellular functions and are potential
therapeutic targets. By virtual screening, we have identified a Rho-specific inhibitor, Rhosin …

We tested the contribution of the small GTPase Rho and its downstream target p160ROCK
during the early stages of axon formation in cultured cerebellar granule neurons …

Abstract Serotonin (5-hydroxytrympamine or 5-HT) is one of the phylogenetically oldest
neurotransmitters, and the serotonergic system is among the earliest developed neuronal …

The neurotransmitter serotonin (5-HT) plays an important role in the regulation of multiple
events in the CNS. We demonstrated recently a coupling between the 5-HT4 receptor and …

Rho–GTPase has been implicated in axon outgrowth. However, not all of the critical steps
controlled by Rho have been well characterized. Using cultured cerebellar granule neurons …

The formation of a neurite, the basis for axons and dendrites, begins with the concerted
accumulation and organization of actin and microtubules. Whereas much is known about the …