The versatile nature of indole containing Schiff bases: A mini review
T Sanjurani, P Barman - Polyhedron, 2023 - Elsevier
Carbonyl compounds such as aldehydes or ketones condense with amines to form Schiff
bases. The synthesis of Schiff bases containing indole rings yields a broad spectrum of …
bases. The synthesis of Schiff bases containing indole rings yields a broad spectrum of …
[HTML][HTML] Allosteric antagonism of the pregnane X receptor (PXR): current-state-of-the-art and prediction of novel allosteric sites
R Kamaraj, M Drastik, J Maixnerova, P Pavek - Cells, 2022 - mdpi.com
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with
high levels of expression in the liver. It not only plays a key role in drug metabolism and …
high levels of expression in the liver. It not only plays a key role in drug metabolism and …
Sonochemical synthesis and biological evaluation of isoquinolin-1 (2H)-one/isoindolin-1-one derivatives: discovery of a positive ago-allosteric modulator (PAAM) of …
Efforts have been devoted for the discovery and development of positive allosteric
modulators (PAMs) of 5-HT 2C R because of their potential advantages over the orthosteric …
modulators (PAMs) of 5-HT 2C R because of their potential advantages over the orthosteric …
Structural optimizations and bioevaluation of NH aporphine analogues as Gq-biased and selective serotonin 5-HT2C receptor agonists
The concept of subtype selectivity and functional bias has recently reshaped current GPCR
drug discovery for G protein-coupled receptors. A series of new NH aporphines with A-ring …
drug discovery for G protein-coupled receptors. A series of new NH aporphines with A-ring …