[HTML][HTML] Targeting HSF1 for cancer treatment: Mechanisms and inhibitor development
Abstract Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive
signaling. In addition to playing critical roles in cellular heat shock response, emerging …
signaling. In addition to playing critical roles in cellular heat shock response, emerging …
A bird's eye view of mitochondrial unfolded protein response in cancer: mechanisms, progression and further applications
X Zhang, Y Fan, K Tan - Cell Death & Disease, 2024 - nature.com
Mitochondria are essential organelles that play critical roles in energy metabolism,
apoptosis and various cellular processes. Accumulating evidence suggests that …
apoptosis and various cellular processes. Accumulating evidence suggests that …
[HTML][HTML] HSF1 Inhibits Antitumor Immune Activity in Breast Cancer by Suppressing CCL5 to Block CD8+ T-cell Recruitment
C Jacobs, S Shah, WC Lu, H Ray, J Wang… - Cancer Research, 2024 - AACR
Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes
cancer cell malignancy. To provide a better understanding of the biological processes …
cancer cell malignancy. To provide a better understanding of the biological processes …
The Interplay between Heat Shock Proteins and Cancer Pathogenesis: A Novel Strategy for Cancer Therapeutics
Simple Summary Heat shock proteins (HSPs) are extensively distributed throughout cells.
They play a crucial role as molecular chaperones and regulate various cellular processes …
They play a crucial role as molecular chaperones and regulate various cellular processes …
Heat Shock Factor 1 Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology
Simple Summary Heat shock factor 1 (HSF1) is a transcription factor crucial for cellular
stress responses. HSF1 activates heat shock proteins (HSPs) in response to proteotoxic …
stress responses. HSF1 activates heat shock proteins (HSPs) in response to proteotoxic …
An increase in HSF1 expression directs human mammary epithelial cells toward a mesenchymal phenotype
Simple Summary Epithelial, compactly packed cells form a protective layer lining the
surfaces of organs and cavities throughout the body. They can lose their features and gain …
surfaces of organs and cavities throughout the body. They can lose their features and gain …
HSF1 Can Prevent Inflammation following Heat Shock by Inhibiting the Excessive Activation of the ATF3 and JUN&FOS Genes
Heat Shock Factor 1 (HSF1), a transcription factor frequently overexpressed in cancer, is
activated by proteotoxic agents and participates in the regulation of cellular stress response …
activated by proteotoxic agents and participates in the regulation of cellular stress response …
HSP70 mediates a crosstalk between the estrogen and the heat shock response pathways
MAD Silveira, F Khadangi, SY Mersaoui, D Naik… - Journal of Biological …, 2023 - ASBMB
Cells respond to multiple signals from the environment simultaneously, which often creates
crosstalk between pathways affecting the capacity to adapt to the changing environment …
crosstalk between pathways affecting the capacity to adapt to the changing environment …
Transcriptional responses to direct and indirect TGFB1 stimulation in cancerous and noncancerous mammary epithelial cells
Background Transforming growth factor beta (TGFβ) is important for the morphogenesis and
secretory function of the mammary gland. It is one of the main activators of the epithelial …
secretory function of the mammary gland. It is one of the main activators of the epithelial …
Combination of magnetic hyperthermia and gene therapy for breast cancer
This study presented a novel breast cancer therapy model that uses magnetic field-
controlled heating to trigger gene expression in cancer cells. We created silica-and amine …
controlled heating to trigger gene expression in cancer cells. We created silica-and amine …