Chromatin immunoprecipitation experiments followed by sequencing (ChIP–seq) detect
protein–DNA binding events and chemical modifications of histone proteins. Challenges in …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …

The human genome encodes the blueprint of life, but the function of the vast majority of its
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …

An essential component of genome function is the syntax of genomic regulatory elements
that determine how diverse transcription factors interact to orchestrate a program of …

Deciphering the ways in which somatic mutations and germline susceptibility variants
cooperate to promote cancer is challenging. Ewing sarcoma is characterized by fusions …

Eukaryotic genomes contain a variety of structured patterns: repetitive elements, binding
sites of DNA and RNA associated proteins, splice sites, and so on. Often, these structured …

ChIP-seq is increasingly used to characterize transcription factor binding and chromatin
marks at a genomic scale. Various tools are now available to extract binding motifs from …

Background RNA: DNA hybrids represent a non-canonical nucleic acid structure that has
been associated with a range of human diseases and potential transcriptional regulatory …

Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing
EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic …