An increase by 70% in new cases of cancer is expected over the next 2 decades, with more
than 8 million people dying each year from the disease, an estimated 13% of all deaths …

Perioperative anaphylaxis is a life-threatening condition with an estimated prevalence of 1:
3,500 to 1: 20,000 procedures and a mortality rate of up to 9%. Clinical presentation involves …

Congenital Zika syndrome (CZS) causes early brain development impairment by affecting
neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins …

Background Drugs are responsible for 40% to 60% of anaphylactic reactions treated in the
emergency department. A global research agenda to address uncertainties in anaphylaxis …

Background Epidemiologic drug allergy data from Latin America are scarce, and there are
no studies on specific procedures focusing on this topic in Latin America. Objective To …

Background Patients with a penicillin allergy label tend to have worse clinical outcomes and
increased healthcare use. Drug provocation tests (DPT) are the gold‐standard in the …

Background Graded challenges are the criterion standard for evaluating adverse drug
reactions (ADR). Evidence-based guidelines regarding the optimal number of steps for …

Drug provocation test (DPT) is the controlled administration of a drug to diagnose immune-or
non-immune-mediated drug hypersensitivity and the last step for accurate recognition of …

Background Graded challenges are performed to exclude hypersensitivity reactions in
patients with a low likelihood of drug allergy. Literature regarding optimal protocols with a …

Background Adverse drug reactions (ADR s) are common. In the absence of a sufficiently
sensitive and specific laboratory test, identification of the culprit drug remains a diagnostic …