Surface modification of TiO 2 nanoparticles with organic molecules and their biological applications

FH Haghighi, M Mercurio, S Cerra… - Journal of Materials …, 2023 - pubs.rsc.org
In recent years, titanium (IV) dioxide nanoparticles (TiO2NPs) have shown promising
potential in various biological applications such as antimicrobials, drug delivery …

[HTML][HTML] Computer-aided nanodrug discovery: recent progress and future prospects

JJ Zheng, QZ Li, Z Wang, X Wang, Y Zhao… - Chemical Society …, 2024 - pubs.rsc.org
Nanodrugs, which utilise nanomaterials in disease prevention and therapy, have attracted
considerable interest since their initial conceptualisation in the 1990s. Substantial efforts …

Chemiluminescent Conjugated Polymer Nanoparticles for Deep-Tissue Inflammation Imaging and Photodynamic Therapy of Cancer

L Li, X Zhang, Y Ren, Q Yuan, Y Wang… - Journal of the …, 2024 - ACS Publications
Deep-tissue optical imaging and photodynamic therapy (PDT) remain a big challenge for the
diagnosis and treatment of cancer. Chemiluminescence (CL) has emerged as a promising …

Molecular Dynamics for the Optimal Design of Functionalized Nanodevices to Target Folate Receptors on Tumor Cells

E Donadoni, G Frigerio, P Siani, S Motta… - ACS Biomaterials …, 2023 - ACS Publications
Atomistic details on the mechanism of targeting activity by biomedical nanodevices of
specific receptors are still scarce in the literature, where mostly ligand/receptor pairs are …

Mechanism of RGD-conjugated nanodevice binding to its target protein integrin α V β 3 by atomistic molecular dynamics and machine learning

G Frigerio, E Donadoni, P Siani, J Vertemara, S Motta… - Nanoscale, 2024 - pubs.rsc.org
Active targeting strategies have been proposed to enhance the selective uptake of
nanoparticles (NPs) by diseased cells, and recent experimental findings have proven the …

Dual responsive magnetic drug delivery nanomicelles with tumor targeting for enhanced cancer chemo/magnetothermal synergistic therapy

J Zhu, Y Yang, J Wang, W Hong, Y Li… - International Journal of …, 2023 - Taylor & Francis
Introduction Stimulus-responsive nanocarrier systems are promising in cancer treatment.
They improve drug stability and facilitate controlled drug release. However, single …

αvβ3 Receptor-targeted acid-responsive controlled-release endosome escape doxorubicin-loaded liposomes for A549/ADR treatment

H Chen, C Liu, S Yu, H Zhou, F Shafiq… - Colloids and Surfaces A …, 2023 - Elsevier
The emergence of liposomes has provided a breakthrough for the clinical use of highly toxic
chemotherapeutic drugs. However, the clinical effects of conventional drug-loaded …

Mechanistic Insights into Toxicity of Titanium Dioxide Nanoparticles at the Micro-and Macro-levels

S Chatterjee, PC Sil - Chemical Research in Toxicology, 2024 - ACS Publications
Titanium oxide nanoparticles (TiO2 NPs) have been regarded as a legacy nanomaterial due
to their widespread usage across multiple fields. The TiO2 NPs have been and are still …

The effect of polymer coating on nanoparticles' interaction with lipid membranes studied by coarse-grained molecular dynamics simulations

E Donadoni, P Siani, G Frigerio, C Milani, Q Cui… - Nanoscale, 2024 - pubs.rsc.org
Nanoparticles'(NPs) permeation through cell membranes, whether it happens via passive or
active transport, is an essential initial step for their cellular internalization. The NPs' surface …

Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery

Y Li, X Li, L Wei, J Ye - Frontiers in Immunology, 2024 - frontiersin.org
In recent decades, nanotechnology has significantly advanced drug delivery systems,
particularly in targeting subcellular organelles, thus opening new avenues for disease …