Bioactive peptides and proteins from centipede venoms

Y Han, PM Kamau, R Lai, L Luo - Molecules, 2022 - mdpi.com
Venoms are a complex cocktail of biologically active molecules, including peptides, proteins,
polyamide, and enzymes widely produced by venomous organisms. Through long-term …

Centipede venom: a potential source of ion channel modulators

A Luo, A Wang, PM Kamau, R Lai, L Luo - International Journal of …, 2022 - mdpi.com
Centipedes are one of the most ancient and successful living venomous animals. They have
evolved spooky venoms to deter predators or hunt prey, and are widely distributed …

Phylogenetic analyses suggest centipede venom arsenals were repeatedly stocked by horizontal gene transfer

EAB Undheim, RA Jenner - Nature Communications, 2021 - nature.com
Venoms have evolved over a hundred times in animals. Venom toxins are thought to evolve
mostly by recruitment of endogenous proteins with physiological functions. Here we report …

Insights into how development and life-history dynamics shape the evolution of venom

JM Surm, Y Moran - EvoDevo, 2021 - Springer
Venomous animals are a striking example of the convergent evolution of a complex trait.
These animals have independently evolved an apparatus that synthesizes, stores, and …

Varying Modes of Selection Among Toxin Families in the Venoms of the Giant Desert Hairy Scorpions (Hadrurus)

GS Nystrom, SA Ellsworth, MJ Ward… - Journal of Molecular …, 2023 - Springer
Venoms are primarily believed to evolve under strong diversifying selection resulting from
persistent coevolution between predator and prey. Recent research has challenged this …

Equipped for Sexual Stings? Male-Specific Venom Peptides in Euscorpius italicus

J Krämer, R Pommerening, R Predel - International Journal of Molecular …, 2022 - mdpi.com
In the animal kingdom, intraspecific variation occurs, for example, between populations,
different life stages, and sexes. For venomous animals, this can involve differences in their …

The arylsulfatase-and phospholipase-rich venom of the plutoniumid centipede Theatops posticus

AN Lane, PD Nash, SA Ellsworth, GS Nystrom… - Toxicon, 2023 - Elsevier
Research on centipede venoms has led to the discovery of a diverse array of novel proteins
and peptides, including those with homology to previously discovered toxin families (eg …

Selection across the three-dimensional structure of venom proteins from North American Scolopendromorph centipedes

SA Ellsworth, RM Rautsaw, MJ Ward… - Journal of molecular …, 2024 - Springer
Gene duplication followed by nucleotide differentiation is one of the simplest mechanisms to
develop new functions for genes. However, the evolutionary processes underlying the …

De novo transcriptomic and proteomic analysis and potential toxin screening of Mesobuthus martensii samples from four different provinces

S Gao, H Liang, Z Shou, Y Yao, Y Lv, J Shang… - Journal of …, 2021 - Elsevier
Highlights•Transcriptome, proteome and bioinformatic analyses were performed on different
originated Mesobuthus martensii.•Most terms in GO and KEGG annotations were consistent …

Development of an LC–MS multivariate nontargeted methodology for differential analysis of the peptide profile of Asian hornet venom (Vespa velutina nigrithorax) …

TN Le, D da Silva, C Colas, E Darrouzet, P Baril… - Analytical and …, 2020 - Springer
Insect venom is a highly complex mixture of bioactive compounds, containing proteins,
peptides, and small molecules. Environmental factors can alter the venom composition and …