The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …

Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

Abstract BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that
modulates environmental carcinogenesis,,. All carriers of inherited heterozygous germline …

Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …

The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

Simple Summary The incidence of renal cell carcinoma (RCC) rises globally with the highest
rates in developed countries. This indicates not only the impact of advanced imaging, but …

To further understand the molecular distinctions between kidney cancer subtypes, we
analyzed exome, transcriptome and copy number alteration data from 167 primary human …

Melanoma is the most deadly of the common skin cancers and its incidence is rapidly
increasing. Approximately 10% of cases occur in a familial context. To date, cyclin …

Approximately 10% of melanoma cases report a relative affected with melanoma, and a
positive family history is associated with an increased risk of developing melanoma …

Renal cell carcinoma of clear-cell type (ccRCC) is an enigmatic tumor type, characterized by
frequent inactivation of the VHL gene (infrequently mutated in other tumor types) …