This Roadmap paper covers the field of precision preclinical x-ray radiation studies in
animal models. It is mostly focused on models for cancer and normal tissue response to …

Simple Summary ALCAM (activated leukocyte cell adhesion molecule) is an important
regulator in human cancers, particularly solid tumours. Its expression in cancer tissues has …

Arteriovenous malformations (AVMs) are an anomaly of the vascular system where feeding
arteries are directly connected to the venous drainage network. While AVMs can arise …

Ionizing radiation is widely used in medicine, both as a diagnostic tool and as a therapeutic
agent. Furthermore, several exposure scenarios, like occupational and environmental …

Aims: The goal of this study was to establish a simple model of 3D endothelial spheroids
with mosaic gene expression using adeno-associated virus (AAV) transduction, with a future …

Radiation has been proposed as a priming agent to induce discriminatory luminal
biomarkers for vascular targeting and drug delivery in disorders such as brain arteriovenous …

Objectives c-Met, a receptor tyrosine kinase, is involved in the growth, invasion and
metastasis of a variety of cancers. In a set of cell lines from several solid tumors, a five-fold …

Endothelial cells are highly sensitive to ionizing radiation, and exposure leads to multiple
adaptive changes. Remarkably, part of this response is the translocation of normally …

In cardiovascular and cerebrovascular biology, control of thrombosis and the coagulation
cascade in ischemic stroke, myocardial infarction, and other coagulopathies is the focus of …

Background Vascular targeting uses molecular markers on the surface of diseased
vasculature for ligand-directed drug delivery to induce vessel occlusion or destruction. In the …