The mast cell is a central player in allergy and asthma. Activation of these cells induces the
release of preformed inflammatory mediators localized in specialized granules and the de …

Mast cells are effector cells of the innate immune system, but because they express Fc
receptors (FcRs), they can be engaged in adaptive immunity by antibodies. Mast cell FcRs …

Bone marrow-derived mast cells (BMMC) have been used extensively as a mast cell model.
BMMC, however, are immature cells that have no known physiological equivalent in tissues …

Adaptor proteins positively or negatively regulate the T cell receptor for antigen (TCR)
signaling cascade. We report that after TCR stimulation, the inhibitory adaptor downstream …

Classically, allergy depends on IgE antibodies and on high-affinity IgE receptors expressed
by mast cells and basophils. This long accepted IgE/FcεRI/mast cell paradigm, on which the …

The aggregation of high-affinity IgE receptors (FcɛRI) on mast cells and basophils has long
been known as the critical event that initiates allergic reactions. Monomeric IgE was recently …

CD4 and CD8 enhancement of FcR-like signaling is discussed as a potential role when
expressed by innate immune cells. CD8 and CD4 are expressed by several cell types that …

Cell activation results from the transient displacement of an active balance between positive
and negative signaling. This displacement depends in part on the engagement of cell …

Elevated IgE levels and increased IgE sensitization to allergens are central features of
allergic asthma. IgE binds to the high-affinity Fcϵ receptor I (FcϵRI) on mast cells, basophils …

Linker for activation of T cells (LAT) is an adaptor protein required for organization of the
signaling machinery downstream of the platelet collagen receptor, the glycoprotein VI …