Pathology and pathogenesis of Chagas heart disease

KM Bonney, DJ Luthringer, SA Kim… - Annual Review of …, 2019 - annualreviews.org
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …

[HTML][HTML] The unsolved jigsaw puzzle of the immune response in Chagas disease

GR Acevedo, MC Girard, KA Gómez - Frontiers in immunology, 2018 - frontiersin.org
Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune
response in a very complex and flowery manner. The history of host-parasite co-evolution …

Antigen presentation by CD1: lipids, T cells, and NKT cells in microbial immunity

NR Cohen, S Garg, MB Brenner - Advances in immunology, 2009 - Elsevier
The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell …

[HTML][HTML] SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of chagas disease–2023

JA Marin-Neto, A Rassi Jr, GMM Oliveira… - Arquivos Brasileiros …, 2023 - SciELO Brasil
SciELO - Brazil - Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com
Cardiomiopatia da Doença de Chagas – 2023 Diretriz da SBC sobre Diagnóstico e Tratamento …

[HTML][HTML] Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease

PMM Guedes, FRS Gutierrez, GK Silva… - PLoS Neglected …, 2012 - journals.plos.org
Background Myocardium damage during Chagas' disease results from the immunological
imbalance between pro-and production of anti-inflammatory cytokines and has been …

Current concepts in immunoregulation and pathology of human Chagas disease

WO Dutra, KJ Gollob - Current opinion in infectious diseases, 2008 - journals.lww.com
Several theories exist to explain differential clinical evolution of Chagas disease. A coherent
understanding of these theories will certainly aid in determining what combination of them …

[HTML][HTML] Cytokine Profiling in Chagas Disease: Towards Understanding the Association with Infecting Trypanosoma cruzi Discrete Typing Units (A BENEFIT TRIAL …

C Poveda, M Fresno, N Gironès, OA Martins-Filho… - PloS one, 2014 - journals.plos.org
Background Chagas disease caused by the protozoan Trypanosoma cruzi is an important
public health problem in Latin America. The immunological mechanisms involved in Chagas …

[HTML][HTML] Cellular and genetic mechanisms involved in the generation of protective and pathogenic immune responses in human Chagas disease

WO Dutra, CAS Menezes, FNA Villani… - Memórias do Instituto …, 2009 - SciELO Brasil
Perhaps one of the most intriguing aspects of human Chagas disease is the complex
network of events that underlie the generation of protective versus pathogenic immune …

[HTML][HTML] Regulatory T cells phenotype in different clinical forms of Chagas' disease

FF de Araujo, DM Vitelli-Avelar… - PLoS neglected …, 2011 - journals.plos.org
CD25High CD4+ regulatory T cells (Treg cells) have been described as key players in
immune regulation, preventing infection-induced immune pathology and limiting collateral …

[HTML][HTML] Intermediate monocytes and cytokine production associated with severe forms of chagas disease

S Gómez-Olarte, NI Bolaños, M Echeverry… - Frontiers in …, 2019 - frontiersin.org
Monocytes are classified according to their CD14 and CD16 expression into classical
(reparative), intermediate (inflammatory), and non-classical. This study assessed the …