Just a few years ago, it had been assumed that the dominant RNA isoforms produced from
eukaryotic genes were variants of messenger RNA, functioning as intermediates in gene …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined
by the genomic sequence. By deep sequencing of RNA from a variety of normal and …

Circular RNAs (circRNAs) are a type of non-coding RNA molecules that lack a 5′-terminal
cap and 3′-terminal poly A tail. A large number of circRNAs have been identified through …

Biological differences between men and women contribute to many sex-specific illnesses
and disorders. Historically, it was argued that such differences were largely, if not …

With each trajectory taken during the ontogeny of an individual, the number of optional
behavioural phenotypes that can be expressed across its life span is reduced. The initial …

Disorders of sex development (DSDs) are conditions affecting development of the gonads or
genitalia. Variants in two key genes, SRY and its target SOX9, are an established cause of …

Sox proteins belong to the HMG box superfamily of DNA-binding proteins and are found
throughout the animal kingdom. They are involved in the regulation of such diverse …

SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex
determination. Recent studies in mice reveal that the major role of SRY is to achieve …

Arguably the most defining moment in our lives is fertilization, the point at which we inherit
either an X or a Y chromosome from our father. The profoundly different journeys of male …