The human circadian system has a period of approximately 24 h and studies on the
consequences of “chornodisruption” have greatly expanded. Lifestyle and environmental …

Over the past 3 billion years, an endogenous circadian rhythmicity has developed in almost
all life forms in which daily oscillations in physiology occur. This allows for anticipation of …

REV-ERB nuclear receptors are potent transcriptional repressors that play an important role
in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its …

Abstract REV-ERBα (NR1D1) is a circadian clock component that functions as a
transcriptional repressor. Due to its role in direct modulation of metabolic genes, REV-ERBα …

Obesity is a major risk factor for the development of illnesses, such as insulin resistance and
hypertension, and has become a serious public health problem. Mammals have developed …

A wide variety of liver functions are regulated daily by the liver circadian clock and via
systemic circadian control by other organs and cells within the gastrointestinal tract as well …

Obesity is a chronic and relapsing public health problem with an extensive list of associated
comorbidities. The worldwide prevalence of obesity has nearly tripled over the last five …

The circadian clock directs nearly all aspects of diurnal physiology, including metabolism.
Current research identifies several major axes by which it exerts these effects, including …

Background While additional research is needed, a number of large epidemiological studies
show an association between circadian disruption and metabolic disorders. Specifically …

Humans as diurnal beings are active during the day and rest at night. This daily oscillation of
behavior and physiology is driven by an endogenous circadian clock not environmental …