Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

Arterial hypertension is a common condition worldwide and an important predictor of several
complicated diseases. Arterial hypertension can be triggered by many factors, including …

Obesity is a worldwide disease that is accompanied by several metabolic abnormalities
such as hypertension, hyperglycemia and dyslipidemia. The accelerated adipose tissue …

The incidence of obesity in the population is increasing at an alarming rate, with this comes
an increased risk of insulin resistance (IR). Obesity and IR increase an individual's risk of …

Understanding the mechanisms linking obesity with hypertension is important in the current
obesity epidemic as it may improve therapeutic interventions. Plasma aldosterone levels are …

We recently found that adipose afferent reflex (AAR) induced by chemical stimulation of
white adipose tissue (WAT) increased sympathetic outflow and blood pressure in normal …

Aldosterone is the primary ligand for the mineralocorticoid receptor (MR) and has been
considered long time a “renal” hormone, acting at this site as a key regulator of plasma …

Methods: We fed animals either a high-fat diet (HFD) or a normal diet (60% kcal from fat or
10% kcal from fat, respectively) for 18 weeks. We then assessed various aspects of adrenal …

Excessive sympathetic activity contributes to the pathogenesis of hypertension and the
progression of the related organ damage. Adipose afferent reflex (AAR) is a sympatho …

Corticosteroids are secreted by the adrenal glands and control the functions of adipose
tissue via the activation of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) …