The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …

Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Introduction: Snakebite is an urgent, unmet global medical need causing significant
morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory …

The World Health Organization has declared snakebite as a neglected tropical disease.
Antivenom administration is the sole therapy against venomous snakebite; however, several …

The venom of the Russell's viper (Daboia siamensis) contains neurotoxic and myotoxic
phospholipase A2 toxins which can cause irreversible damage to motor nerve terminals …

Myotoxin-II, a phospholipase A 2 (PLA 2)-like protein found in Bothrops asper venom,
causes rapid necrosis of muscle fibers in spite of lacking enzymatic activity. This toxic action …

The venoms of Asiatic kraits (Bungarus spp.) contain various neurotoxic phospholipases A 2
(beta-bungarotoxins) which can irreversibly damage motor nerve terminals, resulting in …

Snake envenomation is well known to cause grievous pathological signs, including
haemorrhagic discharge, necrosis, and respiratory distress. However, inflammatory …

Snake bite is a neglected disease that affects millions of people worldwide. WHO reported
approximately 5 million people are bitten by various species of snakes each year, resulting …

Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A 2 (PLA 2)
originally developed to control inflammatory cascades of diseases associated with high or …