Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the
cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible …

The retinoblastoma family of proteins, also known as pocket proteins, includes the product of
the retinoblastoma susceptibility gene and the functionally and structurally related proteins …

Estrogen-induced progression through G 1 phase of the cell cycle is preceded by increased
expression of the G 1-phase regulatory proteins c-Myc and cyclin D1. To investigate the …

p130 is a tumor suppressor of the pocket protein family whose expression is
posttranscriptionally regulated and largely G0 restricted. The mechanism of down-regulation …

It is well known that G1 to S phase transition is tightly regulated by the expression and
phosphorylation of a number of well‐characterized cyclins, cyclin‐dependent kinases and …

Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the
retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription …

The pRb family proteins (pRb1/105, p107, pRb2/p130), collectively referred to as pocket
proteins, are believed to function primarily as regulators of the mammalian cell cycle …

Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence
and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive …

Rb family proteins (pRb/p105, Rb2/p130 and p107) play a key role in cell cycle control and
are worthily involved in transcription repression and tumor suppression. The mechanisms of …