Glial cells play critical roles in the normal development and function of neural circuits, but in
many neurodegenerative diseases, they become dysregulated and may contribute to the …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Huntington's disease (HD) is a fatal neurodegenerative disease caused by mutant HTT gene
expansions of CAG triplet repeat numbers that are inherited in an autosomal dominant …

Virtual dissection of white matter (WM) using diffusion MRI tractography is confounded by its
poor reproducibility. Despite the increased adoption of advanced reconstruction models …

Background: The late myelinating superficial white matter at the juncture of the cortical gray
and white matter comprising the intracortical myelin and short-range association fibers has …

Objective The goal of this work is to study the changes in white matter integrity in R6/2, a
well-established animal model of Huntington's disease (HD) that are captured by ex vivo …

We lack a mechanistic explanation for the stereotyped pattern of white matter loss seen in
Huntington's disease (HD). While the earliest white matter changes are seen around the …

Background: Huntington's disease (HD) is an autosominal dominant neurodegenerative
condition that leads to progressive loss of motor and cognitive functions. Early symptoms in …

Cumulative evidence indicates that the onset and severity of Huntington's disease (HD)
symptoms correlate with connectivity deficits involving specific neuronal populations within …

Huntington's disease (HD) is a monogenic disorder with 100% penetrance. With the advent
of genetic testing in adults, disease-related, structural brain changes can be investigated …